The Soroepidemiologia and Immunobiology laboratory, located on the 4th floor-building 2 of the Instituto de Medicina Tropical de São Paulo, develops scientific research in the areas of diagnosis, pathogenesis and resistance related genes mapping of therapeutic drugs, in infectious and parasitic diseases.

The lab has as its purposes:

  • Promote the formation of researchers in basic and applied area.
  • Serve as a field of education and training for undergraduate and graduate students in health-related areas.
  • Train professionals in the field of health, notably with regard to laboratory activity in tropical diseases.



The Soroepidemiologia and Immunobiology laboratory of the Instituto de Medicina Tropical de São Paulo was created in the early 60 by then-Director of the Institute Prof.. Carlos da Silva Lacaz, laboratory of Immunology – serology.

He was appointed as head of laboratory Dr. Mario e. Caldwell, a doctor and member of the laboratory of clinical analyses Fleury, with vision focused on research in the field of Clinical Immunology, especially in serology.

Dr. Mario Camargo was the Mission of transforming the laboratory Reference Center of the World Health Organization, after specialize in immunofluorescence techniques, train employees and promote courses on the introduction of the Immunofluorescence techniques for professionals of Brazil, Latin America and other countries in the world.

Carefully prepared, the course provided a program of lectures, practices and seminars that put his assistants at the frontier of scientific knowledge. In practical classes the students were learning how to do the conjugated fluorescent, characterize them and use them in different immunofluorescence techniques. This particularity was what gave the course a character, recognized internationally.

For more than 10 years, without interruption, the course was taught and with the advent of new serological tests as standardized and developed in haemagglutination and imunoenzimáticos Testing Laboratory, by request of the who and by its recognition, the course was modernized, expanded and taught for years followed until the mid 90, as of course Introduction to serological tests and Clinical and epidemiological Applications.

So that he could teach the new course with new techniques, the members of the lab have been trained in imunoenzimáticas techniques by renowned researchers as Stratis Avrameas, France, Paul Nakane, United States and Allister Voller, England, at the invitation of the lab came to Brazil and passed their knowledge to the researchers at the Institute of Tropical Medicine.
In addition to the courses, the lab was also trainer of human resources in University area, providing internships and graduate programs for hundreds of students, who today occupy a prominent position in several research centers of Brazil.

It is clear that technological developments have opened new frontiers and challenges. Tests to be applied in the individual diagnosis, the lab went to work in large surveys from. So it was that at the request of the Ministry of health with support from who, coordinated the largest survey to date held in the world ceremony, to meet the serological prevalence of Chagas disease in Brazil. More recently, a new survey seroepidemiological on Chagas disease was done in children of 0 to 5 years, to know if there was still the transmission of the disease through vector or congenital. The lab was the Centre of reference of this project, confirming and validating the initial results made in the Central Laboratory in Goiânia.

Aiming at the future and the introduction of new methodologies in the area of Clinical Immunology, the lab started working with experimental designs and introduced molecular biology techniques in their field of expertise.

The name of the laboratory was changed initially to Serology lab and Soroepidemiologia and later to the current name Soroepidemiologia and Immunobiology laboratory. Made and are part of this evolution in the lab the following teachers of the University of São Paulo.

Dr. Mario Endsfeld Camargo
Dra. Sumie Hoshino Shimizu
Dra. Maria Carolina Soares Guimarães
Dr. Antonio Walter Ferreira
Dr. Benedito Anselmo Peres
Dr. Osvaldo Sunao Nakahara
Dr. Paulo Cesar Cotrim
Dra. Hiro Goto
Dra. Thelma Suely Okay

Text written by Prof. Dr. Antonio Walter Ferreira, retired faculty member of the University of São Paulo, former head of the lab and former Director of the Instituto de Medicina Tropical de São Paulo.



Enzyme-linked immunosorbent assay (ELISA) and Indirect Imunofluorêscencia (IFIS) for antibodies IgG anti-Leishmania spp.
These serological tests are performed to the Clinics of HC/FMUSP:

  • Dermatology, ENT, Infectious Diseases and internal medicine
  • Instituto da Criança HC-FMUSP
  • Santa Casa de Misericórdia de São Paulo
  • Instituto de Infectologia Emílio Ribas
  • Hospital Darcy Vargas

Contact: MSc. Beatrice J. Celeste
(11) 3061-7027

Enzyme-linked immunosorbent assay (ELISA) for the detection of IgG antibodies anti-Toxocara spp.
This test is performed for the following institutions:

  • Instituto da Criança-HC-FMUSP
  • Instituto de Infectologia Emílio Ribas

Contact: Dr. Gita R. Elefant
(11) 3061-7060


(11) 3061-7028